Aktieris plašāku popularitāti iemantoja ar lomu 1982. gada filmā "Rembo I: pirmās asinis" ("First Blood"), kurā atveidoja šīs filmu sērijas zvaigznes Silvestra Stalones (Sylvester Stallone) varoņa Džona Rembo pretinieku - šerifu Vilu Tīslu.

Pirms tam septiņdesmitajos gados staltais aktieris bija redzams vairākos seriālos - "Kojak", "MASH", "Dallas" un "Dynasty".

Otra zīmīgākā loma ir 1995. gada komēdija "Tommy Boy".

Aktieris saņēmis vairākas nozīmīgas balvas - Zelta globusu, divas "Tony" un sešas "Emmy" balvas.

Paralēli kino Braiens Denehijs daudz strādājis arī teātrī, galvenokārt Čikāgā.

Aktieri sociālajos tīklos piemin daudzi kolēģi, arī Stalone, bilstot, ka viņš bija vienkārši lielisks aktieris.

The great actor Brian Dennehy has passed away. He simply was a great actor ... He also was a Vietnam vet that helped me very much building the character of RAMBO The world has lost a great artist. #First Blood https://t.co/knL4rROymL

— Sylvester Stallone (@TheSlyStallone) April 16, 2020

Just devastated to learn that the magnificent Brian Dennehy has died. They is no one i enjoyed working with more. And there are few friends as valued in my life. I took this photo backstage when we were in Love Letters. He loved my pup Bowie. pic.twitter.com/s55Cc37lFy

— Mia Farrow (@MiaFarrow) April 16, 2020